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Tu, Zhen ; Li, Runtong ; Li, Yong ; Wang, Gang ; Wu, Di ; Hui, Pan ; Su, Li ; Jin, Depeng ( , Proceedings of the ACM on Interactive, Mobile, Wearable and Ubiquitous Technologies)
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Wang, Yan ; Su, Li ; Wang, Qiang ; Zhang, Li ; Luan, Yepeng ( , Drug Development Research)
Abstract Histone deacetylases have proven to be promising targets for the development of anticancer drugs. In this work, we reported the design and synthesis of a series of 20 novel hydroxamic acid‐based histone deacetylase inhibitors with 4‐piperidin‐4‐yl‐triazole as the core structure. Five newly obtained compounds displayed excellent HDAC6 inhibitory activities. Among them, compounds WY‐12 and WY‐15 also exhibited excellent antiproliferative activities against six human tumor cell lines. WY‐15 could increase the level of acetylated histone H3 in a dose‐dependent manner. Furthermore, WY‐15 remarkably induced cell cycle arrest of Sy5y cancer cells in G0/G1phase. Finally, the high potency of compound WY‐15 toward HDAC6 was rationalized by molecular docking study.
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Peng, Shouzhong ; Zhao, Weisheng ; Qiao, Junfeng ; Su, Li ; Zhou, Jiaqi ; Yang, Hongxin ; Zhang, Qianfan ; Zhang, Youguang ; Grezes, Cecile ; Amiri, Pedram Khalili ; et al ( , Applied Physics Letters)